- Like a Deerkovsky in a Headlight- The First mission involves you being introduced to Kris Deerkovski who is then kidnapped by Eugene Griffs and Carla Tompkins. He is then pushed in front of a bus driven by thew Tompkin siblings. It is your goal to Prevent him from dying by Somehow stopping the Train.
Introduces you to the world of racing on Marten Island he has you race his friends and beat the Time limit of 5:20:00
- Tricks of the triad-Kinzie Kensington taps into the Triads websites and takes money out of their account and wires it to your account. You must protect her from Angry Triad thugs lead by Donnie.
- Come get some-A wrestler who is revealed to be one of Dolph Oberlanders henchmen insults Angel De La muerte. Angel than asks the Player if he can enter Murderbrawl XXXII to shut him up.This mission is unlocked when you takeover 25% of Freemason City.
- Ho Ho Ho-A pimp named Deve'reaux who is on the payroll of Tajiri Kaneda has stolen Zimos's Hos. He than stows away on Tajiri Kanedas boat the SS Bushwick. It is your goal to hunt him down and take the Hos to safety.
- Freemason City are you ready?-After the 2nd mission Gat takes you on a tour of Freemason City. You then bump into an old friend Benjamin King.
- Party Like its wait what year is it?-You crash a party orchestrated by Scottie Pippen and hold the partygoers hostage. This mission is vaugely similar to a scene in the show 24.