The Supreme Crime Syndicate of Stilwater (or SCSS) is a large gang consisting of supervillains and criminals, with their one goal of destroying the 3rd Street Saints and hopes of power over Stilwater, Steelport and beyond. It merges resources used by the Ultor Corporation, Zin Empire and the Syndicate.
With the increasing power of the 3rd Street Saints, the late Phillipe Loren's brother Jacques Loren uses his wealth and power to collect together a lot of criminals and supervillains with the goal of defeating the Saints. Using resources left over from his brother's fallen Syndicate, combined with technology from the Ultor Corporation and the Zin Empire, he manages to create the biggest criminal empire.
- Jacques Loren - (Founder)
- Mr. Sinister (Deceased)
- Dexter Jackson (Deceased)
- Mister Purple (Replacing Mr. Sinister)
- Eddie "Big Pussy" Pryor (deceased)
- The G-Man