The Wiseguys are traditionally based in Italy, near the city of Rome, although most Mafia families are based in Sicily and Naples. They mainly deal in gambling, gunrunning, pimping, extortion, stolen goods, and white collar crimes. The Wiseguys avoid the drug trade at all costs though. Traditionally, they are allied with the Third Street Saints and negotiated an alliance with the Deckers, and their main enemies are the Luchadores, Morningstar, Vice Kings, and The Syndicate. Wiseguys tend to be less thuggish than most gangs, but are just as fierce and better organized.
Their leader is the charismatic and intelligent Nino Genova, an Italian immigrant and founder of the Wiseguys.